TBA-7371

Search structure


Synonyms:	AZ-7371 Tba-7371
Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	R3T98GBE3C

Structure


InChI Key	VDRYGTNDKXIPSK-UHFFFAOYSA-N
Smile	COc1ncnc(Cn2cc(C(=O)NCCO)c3ncc(C)cc32)c1C
InChI	InChI=1S/C18H21N5O3/c1-11-6-15-16(20-7-11)13(17(25)19-4-5-24)8-23(15)9-14-12(2)18(26-3)22-10-21-14/h6-8,10,24H,4-5,9H2,1-3H3,(H,19,25)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H21N5O3
Molecular Weight	355.4
AlogP	1.22
Hydrogen Bond Acceptor	7.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	6.0
Polar Surface Area	102.16
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	26.0

Pharmacology

Action	Mechanism of Action	Reference
INHIBITOR	FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase inhibitor	PubMed Other

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Phosphodiesterase Phosphodiesterase 6 Phosphodiesterase 6A	-	6000	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 6 Phosphodiesterase 6B	-	6000	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 6 Phosphodiesterase 6C	-	6000	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 6 Phosphodiesterase 6D	-	6000	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 6 Phosphodiesterase 6G	-	6000	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 6 Phosphodiesterase 6H	-	6000	-	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Tuberculosis, Pulmonary	2	D014397	ClinicalTrials
Tuberculosis	1	D014376	ClinicalTrials

Cross References

Resources	Reference
ChEMBL	CHEMBL3109802
DrugBank	DB16243
FDA SRS	R3T98GBE3C
PubChem	72792692
SureChEMBL	SCHEMBL16395186
ZINC	ZINC000103248024

CONTENTS