OLACAFTOR

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: RZ7027HK8F

Structure
InChI Key NHOUNZMCSIHKHJ-FQEVSTJZSA-N
Smile CC(C)COc1cc(F)cc(-c2ccc(C(=O)NS(=O)(=O)c3ccccc3)c(N3C[C@@H](C)CC3(C)C)n2)c1
InChI
InChI=1S/C29H34FN3O4S/c1-19(2)18-37-23-14-21(13-22(30)15-23)26-12-11-25(27(31-26)33-17-20(3)16-29(33,4)5)28(34)32-38(35,36)24-9-7-6-8-10-24/h6-15,19-20H,16-18H2,1-5H3,(H,32,34)/t20-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C29H34FN3O4S
Molecular Weight 539.67
AlogP 5.67
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 8.0
Polar Surface Area 88.6
Molecular species ACID
Aromatic Rings 3.0
Heavy Atoms 38.0

Pharmacology

Action Mechanism of Action Reference
POSITIVE MODULATOR Cystic fibrosis transmembrane conductance regulator positive modulator PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Cystic Fibrosis 2 D003550 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4297649
DrugBank DB16262
FDA SRS RZ7027HK8F
PubChem 121250885
SureChEMBL SCHEMBL17646981
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