BMS-852927

Search structure
Synonyms:
Status: Phase 1
Entry Type: Small molecule
Molecule Category: UNKNOWN

Physicochemical Descriptors

Property Name Value
Molecular Formula C29H28Cl2F2N2O4S
Molecular Weight 609.52
AlogP 6.57
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 7.0
Polar Surface Area 92.42
Molecular species None
Aromatic Rings 4.0
Heavy Atoms 40.0

Pharmacology

Action Mechanism of Action Reference
MODULATOR LXR-alpha modulator PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group H Nuclear hormone receptor subfamily 1 group H member 3
0.6-24 69 - 12 83
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group I Nuclear hormone receptor subfamily 1 group I member 2
1000 - - - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 2 Nuclear hormone receptor subfamily 2 group B Nuclear hormone receptor subfamily 2 group B member 1
- - - 12 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Hypercholesterolemia 1 D006937 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL3545047
CONTENTS