| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | R7O0O4110G |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C20H23ClN6O2 |
| Molecular Weight | 414.9 |
| AlogP | 4.6 |
| Hydrogen Bond Acceptor | 7.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 93.1 |
| Molecular species | None |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 29.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Focal adhesion kinase 1 inhibitor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Fak family
|
- | 0.4-15 | - | 0.4 | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Meningioma | 2 | D008579 | ClinicalTrials |
| Hypertension, Pulmonary | 1 | D006976 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3544967 |
| FDA SRS | R7O0O4110G |
| PubChem | 46214930 |
CONTENTS