EVT-101

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: B55T45AA8F

Structure
InChI Key BOVUHBFXPNLTKF-UHFFFAOYSA-N
Smile Cc1nccn1Cc1cc(-c2ccc(F)c(C(F)F)c2)cnn1
InChI
InChI=1S/C16H13F3N4/c1-10-20-4-5-23(10)9-13-6-12(8-21-22-13)11-2-3-15(17)14(7-11)16(18)19/h2-8,16H,9H2,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C16H15Cl2F3N4
Molecular Weight 391.22
AlogP 3.77
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 4.0
Polar Surface Area 43.6
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 23.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Glutamate NMDA receptor; GRIN1/GRIN2B antagonist
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor NMDA receptor
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Indications

Mesh Heading Maximum Phase Mesh ID Reference
Depressive Disorder 2 D003866 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL3545349
DrugBank DB05956
FDA SRS B55T45AA8F
PubChem 72941990
ChEMBL CHEMBL3545350
FDA SRS 14DN1WB87S
PDB 5SM
PubChem 72941990
SureChEMBL SCHEMBL2348935
ZINC ZINC000118695150
CONTENTS