| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C25H30N8O4 |
| Molecular Weight | 506.57 |
| AlogP | 1.48 |
| Hydrogen Bond Acceptor | 9.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 8.0 |
| Polar Surface Area | 143.79 |
| Molecular species | None |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 37.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Fibroblast growth factor receptor 4 inhibitor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase FGFR family
|
- | 1.26-15 | - | - | - | |
|
Enzyme
Transferase
|
- | - | - | - | 5.96 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Carcinoma, Hepatocellular | 1 | D006528 | ClinicalTrials |
| Neoplasms | 1 | D009369 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3545293 |
CONTENTS