AR9281

Search structure


Synonyms:	Ar9281
Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	4HA03Q8EZ9

Structure


InChI Key	HUDQLWBKJOMXSZ-UHFFFAOYSA-N
Smile	CC(=O)N1CCC(NC(=O)NC23CC4CC(CC(C4)C2)C3)CC1
InChI	InChI=1S/C18H29N3O2/c1-12(22)21-4-2-16(3-5-21)19-17(23)20-18-9-13-6-14(10-18)8-15(7-13)11-18/h13-16H,2-11H2,1H3,(H2,19,20,23)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H29N3O2
Molecular Weight	319.45
AlogP	2.27
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	2.0
Polar Surface Area	61.44
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	23.0

Pharmacology

Action	Mechanism of Action	Reference
INHIBITOR	Epoxide hydratase inhibitor	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Protease Serine protease Serine protease SC clan Serine protease S33 family	-	7-57	-	20	-
Enzyme	-	7-57	-	20	-
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	-	-	-	5

Cross References

Resources	Reference
ChEMBL	CHEMBL436774
DrugBank	DB06345
FDA SRS	4HA03Q8EZ9
SureChEMBL	SCHEMBL654229
ZINC	ZINC000036330562

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