Synonyms: | |
Status: | Phase 3 |
Entry Type: | Small molecule |
Molecule Category: | UNKNOWN |
UNII: | ICJ93X8X90 |
InChI Key | JZZFDCXSFTVOJY-UHFFFAOYSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C24H27Cl3FN5O3 |
Molecular Weight | 558.87 |
AlogP | 4.39 |
Hydrogen Bond Acceptor | 7.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 9.0 |
Polar Surface Area | 88.61 |
Molecular species | NEUTRAL |
Aromatic Rings | 3.0 |
Heavy Atoms | 34.0 |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase EGFR family
|
- | 2-7 | - | - | - | |
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase PDGFR family
|
- | - | 3900-7800 | - | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Breast Neoplasms | 2 | D001943 | ClinicalTrials |
Lung Neoplasms | 2 | D008175 | ClinicalTrials |
Carcinoma, Non-Small-Cell Lung | 1 | D002289 | ClinicalTrials |
Resources | Reference |
---|---|
ChEMBL | CHEMBL545315 |
EPA CompTox | DTXSID80183143 |
FDA SRS | ICJ93X8X90 |
PubChem | 156413 |
SureChEMBL | SCHEMBL731396 |