OMIDENEPAG ISOPROPYL

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: G0G0H52U6K

Structure
InChI Key VIQCWEGEHRBLAC-UHFFFAOYSA-N
Smile CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1
InChI
InChI=1S/C26H28N6O4S/c1-20(2)36-26(33)17-28-25-8-3-6-22(30-25)19-31(37(34,35)24-7-4-13-27-16-24)18-21-9-11-23(12-10-21)32-15-5-14-29-32/h3-16,20H,17-19H2,1-2H3,(H,28,30)

Physicochemical Descriptors

Property Name Value
Molecular Formula C26H28N6O4S
Molecular Weight 520.62
AlogP 3.42
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 11.0
Polar Surface Area 119.31
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 37.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Prostanoid EP2 receptor agonist
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Prostanoid receptor
1.1 4180 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Glaucoma, Open-Angle 4 D005902 FDA
Ocular Hypertension 4 D009798 FDA
Glaucoma 3 D005901 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4297666
DrugBank DB15071
DrugCentral 5312
FDA SRS G0G0H52U6K
PubChem 44230999
SureChEMBL SCHEMBL15414827
CONTENTS