| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | VI5LR1EU47 |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C12H12F3N |
| Molecular Weight | 227.23 |
| AlogP | 2.88 |
| Hydrogen Bond Acceptor | 1.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 0.0 |
| Polar Surface Area | 12.03 |
| Molecular species | None |
| Aromatic Rings | 1.0 |
| Heavy Atoms | 16.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| PARTIAL AGONIST | Neuronal acetylcholine receptor; alpha4/beta2 partial agonist |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Ion channel
Ligand-gated ion channel
Nicotinic acetylcholine receptor
Nicotinic acetylcholine receptor alpha subunit
|
- | - | - | 102 | - | |
|
Ion channel
Ligand-gated ion channel
Nicotinic acetylcholine receptor
Nicotinic acetylcholine receptor beta subunit
|
- | - | - | 102 | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Depressive Disorder, Major | 2 | D003865 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3707250 |
| FDA SRS | VI5LR1EU47 |
| PubChem | 11498153 |
CONTENTS