(D)-SERINE

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 1K77H2Z9B1

Structure
InChI Key MTCFGRXMJLQNBG-UWTATZPHSA-N
Smile N[C@H](CO)C(=O)O
InChI
InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C3H7NO3
Molecular Weight 105.09
AlogP -1.61
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 2.0
Polar Surface Area 83.55
Molecular species ZWITTERION
Aromatic Rings 0.0
Heavy Atoms 7.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Transferase
- - - - 12.9-26.21
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -16.26--7.83
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor NMDA receptor
1000-1130 300 - 316.23 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC01 family of amino acid transporters
- 3937000 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC03 and SLC07 families of heteromeric amino acid transporters (HATs) SLC07 Cationic amino acid transporter/glycoprotein-associated family
- 9400 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- 4913000 - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC36 family of proton-coupled amino acid transporters
- - - 22000000 -
Transporter
- 1581000-2592000 - 22000000 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Schizophrenia 3 D012559 ClinicalTrials
Psychotic Disorders 3 D011618 ClinicalTrials
Cocaine-Related Disorders 2 D019970 ClinicalTrials

Cross References

Resources Reference
ChEBI 16523
ChEMBL CHEMBL285123
DrugBank DB03929
EPA CompTox DTXSID9041021
FDA SRS 1K77H2Z9B1
Human Metabolome Database HMDB0003406
Guide to Pharmacology 4171
KEGG C00740
PDB DSN
SureChEMBL SCHEMBL43094
ZINC ZINC000000895342
CONTENTS