| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C22H27ClN4O |
| Molecular Weight | 398.94 |
| AlogP | 5.46 |
| Hydrogen Bond Acceptor | 5.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 6.0 |
| Polar Surface Area | 51.45 |
| Molecular species | None |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 28.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| ANTAGONIST | Corticotropin releasing factor receptor 1 antagonist |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Membrane receptor
Family B G protein-coupled receptor
Peptide receptor (family B GPCR)
Corticotropin releasing factor receptor
Corticotropin releasing factor receptor
|
40 | 4 | - | - | - |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3545034 |
CONTENTS