PF-5190457

Search structure


Synonyms:	Pf-05190457 Pf-5190457
Status:	Phase 2
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	FF33NL9U5G

Structure


InChI Key	ZIUDADZJCKGWKR-AREMUKBSSA-N
Smile	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4cn5cc(C)sc5n4)CC3)C2)ncn1
InChI	InChI=1S/C29H32N6OS/c1-19-11-25(31-18-30-19)22-3-5-24-21(12-22)4-6-26(24)35-16-29(17-35)7-9-33(10-8-29)27(36)13-23-15-34-14-20(2)37-28(34)32-23/h3,5,11-12,14-15,18,26H,4,6-10,13,16-17H2,1-2H3/t26-/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C29H32N6OS
Molecular Weight	512.68
AlogP	4.62
Hydrogen Bond Acceptor	7.0
Hydrogen Bond Donor	0.0
Number of Rotational Bond	4.0
Polar Surface Area	66.63
Molecular species	BASE
Aromatic Rings	4.0
Heavy Atoms	37.0

Pharmacology

Action	Mechanism of Action	Reference
INVERSE AGONIST	Ghrelin receptor inverse agonist	PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	6900	-	-	-
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) GRP-related receptor	-	-	-	7-7
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	-	3700	-	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Alcoholism	2	D000437	ClinicalTrials
Diabetes Mellitus, Type 2	1	D003924	ClinicalTrials
Alcohol Drinking	1	D000428	ClinicalTrials

Cross References

Resources	Reference
ChEMBL	CHEMBL3287218
DrugBank	DB14870
FDA SRS	FF33NL9U5G
Guide to Pharmacology	9060
PubChem	58438464
SureChEMBL	SCHEMBL2445443
ZINC	ZINC000072317087

CONTENTS