| Synonyms: | |
| Status: | Phase 3 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 74QU6P2934 |
Structure
| InChI Key | MREBEPTUUMTTIA-PCLIKHOPSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C23H28ClN5O3 |
| Molecular Weight | 457.96 |
| AlogP | 3.23 |
| Hydrogen Bond Acceptor | 6.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 8.0 |
| Polar Surface Area | 72.6 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 32.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Ion channel
Voltage-gated ion channel
Potassium channels
Voltage-gated potassium channel
|
- | 400-1413 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Heart Failure | 2 | D006333 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| ChEBI | 34545 |
| ChEMBL | CHEMBL123558 |
| FDA SRS | 74QU6P2934 |
| Guide to Pharmacology | 2588 |
| KEGG | C13777 |
| PubChem | 60939 |
| SureChEMBL | SCHEMBL26354 |
| ZINC | ZINC000021983255 |
CONTENTS