OLODANRIGAN

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: P0FN522VTO

Structure
InChI Key GHBCIXGRCZIPNQ-MHZLTWQESA-N
Smile COc1ccc2c(c1OCc1ccccc1)C[C@@H](C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2
InChI
InChI=1S/C32H29NO5/c1-37-28-18-17-25-20-33(31(34)29(23-13-7-3-8-14-23)24-15-9-4-10-16-24)27(32(35)36)19-26(25)30(28)38-21-22-11-5-2-6-12-22/h2-18,27,29H,19-21H2,1H3,(H,35,36)/t27-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C32H29NO5
Molecular Weight 507.59
AlogP 5.44
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 8.0
Polar Surface Area 76.07
Molecular species ACID
Aromatic Rings 4.0
Heavy Atoms 38.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Angiotensin II type 2 (AT-2) receptor antagonist Other PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Angiotensin receptor
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Indications

Mesh Heading Maximum Phase Mesh ID Reference
Diabetic Neuropathies 2 D003929 ClinicalTrials
Neuralgia, Postherpetic 2 D051474 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL34124
DrugBank DB16266
FDA SRS P0FN522VTO
Guide to Pharmacology 8374
PubChem 9937291
SureChEMBL SCHEMBL421411
ZINC ZINC000001483494
CONTENTS