PRATOSARTAN

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 66VLQ6E6DL

Structure
InChI Key KCTFTBCZZUBAKN-UHFFFAOYSA-N
Smile CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CCCC2
InChI
InChI=1S/C25H26N6O/c1-2-7-23-26-21-10-5-6-11-22(32)24(21)31(23)16-17-12-14-18(15-13-17)19-8-3-4-9-20(19)25-27-29-30-28-25/h3-4,8-9,12-15H,2,5-7,10-11,16H2,1H3,(H,27,28,29,30)

Physicochemical Descriptors

Property Name Value
Molecular Formula C25H26N6O
Molecular Weight 426.52
AlogP 4.64
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 6.0
Polar Surface Area 89.35
Molecular species ACID
Aromatic Rings 4.0
Heavy Atoms 32.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Solute carrier family 22 member 12 inhibitor PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Angiotensin receptor
- 1-1 0-0 - -

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 32041
ChEMBL CHEMBL41194
FDA SRS 66VLQ6E6DL
PubChem 9802561
SureChEMBL SCHEMBL93595
ZINC ZINC000003786304
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