DIHOMO-GAMMA-LINOLENIC ACID

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: FC398RK06S

Structure
InChI Key HOBAELRKJCKHQD-QNEBEIHSSA-N
Smile CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)O
InChI
InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H34O2
Molecular Weight 306.49
AlogP 6.44
Hydrogen Bond Acceptor 1.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 15.0
Polar Surface Area 37.3
Molecular species ACID
Aromatic Rings 0.0
Heavy Atoms 22.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Protease Serine protease Serine protease PA clan Serine protease S1A subfamily
- 30000-75000 - - -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Leukotriene receptor
- 2000 - - -
Membrane receptor
- 30000-75000 - - -
Surface antigen
- 30000-75000 - - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 1
- 1400-1400 - - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 2
- 4300 - - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 3
- 2400 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Dermatitis, Atopic 2 D003876 ClinicalTrials

Cross References

Resources Reference
ChEBI 53486
ChEMBL CHEMBL465183
DrugBank DB00154
FDA SRS FC398RK06S
Human Metabolome Database HMDB0002925
Guide to Pharmacology 9775
KEGG C03242
PDB LAX
PharmGKB PA164743249
SureChEMBL SCHEMBL842729
ZINC ZINC000004521470
CONTENTS