FLUFENAMIC ACID

Search structure
Synonyms:
Status: Approved
Entry Type: Small molecule
Molecule Category: Parent
ATC: M01AG03
UNII: 60GCX7Y6BH

Structure
InChI Key LPEPZBJOKDYZAD-UHFFFAOYSA-N
Smile O=C(O)c1ccccc1Nc1cccc(C(F)(F)F)c1
InChI
InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H10F3NO2
Molecular Weight 281.23
AlogP 4.15
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 49.33
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 20.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C9
- - - 115904420522271.9 -
Enzyme Hydrolase
- - - - 0.5791
Enzyme Ligase
- - - 0.01 -
Enzyme Oxidoreductase
- 50-8630 - - 25-64
Enzyme Transferase
- - - - 6.16-29.44
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -1.09-30.59
Ion channel Ligand-gated ion channel Acid-sensing ion channel
2600000 - - - -
Ion channel Voltage-gated ion channel Potassium channels Two-pore domain potassium channel
100000 - - - -
Ion channel Voltage-gated ion channel Transient receptor potential channel
6918.31-24000 70000-70000 - - -
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- - - - 26.7
Membrane receptor Taste family G protein-coupled receptor Taste receptor (taste family GPCR)
430 - - - -
Secreted protein
- 2900 30 - 98
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4
- - - - 42
Transcription factor
- 220000 73000-84000 - 42
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 211.28
Transporter Primary active transporter Oxidoreduction-driven transporters
- - - - 18

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 42638
ChEMBL CHEMBL23588
DrugBank DB02266
DrugCentral 1193
EPA CompTox DTXSID7023063
FDA SRS 60GCX7Y6BH
Guide to Pharmacology 2447
KEGG C13038
PDB FLF
PharmGKB PA166049190
PubChem 3371
SureChEMBL SCHEMBL17497
ZINC ZINC000000086535
CONTENTS