CINACIGUAT

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 59K0Y58UAD

Structure
InChI Key WPYWMXNXEZFMAK-UHFFFAOYSA-N
Smile O=C(O)CCCCN(CCc1ccccc1OCc1ccc(CCc2ccccc2)cc1)Cc1ccc(C(=O)O)cc1
InChI
InChI=1S/C36H39NO5/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41)

Physicochemical Descriptors

Property Name Value
Molecular Formula C36H39NO5
Molecular Weight 565.71
AlogP 7.05
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 17.0
Polar Surface Area 87.07
Molecular species ZWITTERION
Aromatic Rings 4.0
Heavy Atoms 42.0

Pharmacology

Action Mechanism of Action Reference
ACTIVATOR Soluble guanylate cyclase activator PubMed PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Heart Failure 2 D006333 ClinicalTrials
Heart Failure 2 D006333 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 142433
ChEMBL CHEMBL1236936
DrugBank DB16126
FDA SRS 59K0Y58UAD
Guide to Pharmacology 5168
PDB Z90
PubChem 9808022
SureChEMBL SCHEMBL249267
ZINC ZINC000003934935
CONTENTS