| Synonyms: | |
| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 0282IF4JC8 |
Structure
| InChI Key | AGBSXNCBIWWLHD-FQEVSTJZSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C26H24Cl2N6O4 |
| Molecular Weight | 555.42 |
| AlogP | 4.69 |
| Hydrogen Bond Acceptor | 9.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 6.0 |
| Polar Surface Area | 104.37 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 38.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Other nuclear protein
|
- | - | - | 0 | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Neoplasms | 2 | D009369 | ClinicalTrials |
| Primary Myelofibrosis | 1 | D055728 | ClinicalTrials |
| Leukemia, Myeloid, Acute | 1 | D015470 | ClinicalTrials |
| Liposarcoma | 1 | D008080 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3653256 |
| DrugBank | DB16331 |
| FDA SRS | 0282IF4JC8 |
| PDB | 9QW |
| PubChem | 71678098 |
| SureChEMBL | SCHEMBL15142060 |
CONTENTS