MIVAVOTINIB

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 8QR88H79VX

Structure
InChI Key MJHOMTRKVMKCNE-NWDGAFQWSA-N
Smile Cn1cc(-c2nc(N[C@@H]3CCCC[C@@H]3N)c(F)c3c2C(=O)NC3)cn1
InChI
InChI=1S/C17H21FN6O/c1-24-8-9(6-21-24)15-13-10(7-20-17(13)25)14(18)16(23-15)22-12-5-3-2-4-11(12)19/h6,8,11-12H,2-5,7,19H2,1H3,(H,20,25)(H,22,23)/t11-,12+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H21FN6O
Molecular Weight 344.39
AlogP 1.55
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 3.0
Polar Surface Area 97.86
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 25.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase CAMK1 family CAMK protein kinase CHK1 subfamily
- 50 - - 84
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase CAMK1 family CAMK protein kinase MARK subfamily
- - - - 52
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase CAMK1 family CAMK protein kinase NuaK subfamily
- - - - 63
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase CAMK1 family CAMK protein kinase QIK subfamily
- - - - 72
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase PHk family
- 226 - - 66
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase RAD53 family
- - - - 63
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase TSSK family
- - - - 71
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase KHS subfamily
- - - - 57
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase PAKB subfamily
- 76 - - 67
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase IRAK family
- - - - 51
Enzyme Kinase Protein Kinase TKL protein kinase group TKL protein kinase LRRK family
- - - - 70-74
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Abl family
- - - - 52-63
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Axl family
- - - - 68
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Eph family
- 31 - - 59
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Fak family
- - - - 50
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Fer family
- 51 - - 62
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase JakA family
- 114 - - 53
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase JakB family
- 114 - - 53
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family
- 5-22 - - 52-81
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Ret family
- 8-19 - - 99-103
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Sev family
- - - - 57
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Src family
- - - - 59
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Syk family
10 2-3 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Trk family
- - - - 59
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family
- 88-135 - - 68

Cross References

Resources Reference
ChEMBL CHEMBL3979920
FDA SRS 8QR88H79VX
Guide to Pharmacology 9600
PDB 7KG
PubChem 53252276
SureChEMBL SCHEMBL1987799
CONTENTS