| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | VK9OS8R205 |
Structure
| InChI Key | PKKNCEXEVUFFFI-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C27H39N3O |
| Molecular Weight | 421.63 |
| AlogP | 6.63 |
| Hydrogen Bond Acceptor | 2.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 44.37 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 31.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Acyl coenzyme A:cholesterol acyltransferase 1 inhibitor | PubMed |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
|
- | 37-52 | - | - | - |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL46423 |
| DrugBank | DB16254 |
| FDA SRS | VK9OS8R205 |
| PDB | ROV |
| PubChem | 131679 |
| SureChEMBL | SCHEMBL1119314 |
CONTENTS