SNX 5422

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: BF52J69Q8T

Structure
InChI Key AVDSOVJPJZVBTC-CTYIDZIISA-N
Smile CC1(C)CC(=O)c2c(C(F)(F)F)nn(-c3ccc(C(N)=O)c(N[C@H]4CC[C@H](OC(=O)CN)CC4)c3)c2C1
InChI
InChI=1S/C25H30F3N5O4/c1-24(2)10-18-21(19(34)11-24)22(25(26,27)28)32-33(18)14-5-8-16(23(30)36)17(9-14)31-13-3-6-15(7-4-13)37-20(35)12-29/h5,8-9,13,15,31H,3-4,6-7,10-12,29H2,1-2H3,(H2,30,36)/t13-,15-

Physicochemical Descriptors

Property Name Value
Molecular Formula C25H30F3N5O4
Molecular Weight 521.54
AlogP 3.37
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 6.0
Polar Surface Area 142.33
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 37.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Heat shock protein HSP90 inhibitor PubMed ClinicalTrials PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Other cytosolic protein
- 38 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 2 D009369 ClinicalTrials
Leukemia 1 D007938 ClinicalTrials
Lymphoma 1 D008223 ClinicalTrials
Hematologic Neoplasms 1 D019337 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL1195136
DrugBank DB06070
FDA SRS BF52J69Q8T
SureChEMBL SCHEMBL1220790
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