Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: S6G4R7DI1C

Structure

InChI Key YPFZMBHKIVDSNR-UHFFFAOYSA-N
Smile CCOc1ncc(S(=O)(=O)N2CCN(CC)CC2)cc1-c1nc2c(CC)n(CCOC)nc2c(=O)[nH]1
InChI
InChI=1S/C23H33N7O5S/c1-5-18-19-20(27-30(18)12-13-34-4)22(31)26-21(25-19)17-14-16(15-24-23(17)35-7-3)36(32,33)29-10-8-28(6-2)9-11-29/h14-15H,5-13H2,1-4H3,(H,25,26,31)

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H33N7O5S
Molecular Weight 519.63
AlogP 1.12
Hydrogen Bond Acceptor 10.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 10.0
Polar Surface Area 135.54
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 36.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Phosphodiesterase 5A inhibitor PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Phosphodiesterase Phosphodiesterase 5 Phosphodiesterase 5A
- 1 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Prostatic Hyperplasia 2 D011470 ClinicalTrials
Urinary Bladder, Overactive 2 D053201 ClinicalTrials
Erectile Dysfunction 2 D007172 ClinicalTrials
Pulmonary Disease, Chronic Obstructive 1 D029424 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL1928262
DrugBank DB11902
FDA SRS S6G4R7DI1C
Guide to Pharmacology 6558
PubChem 135536943
SureChEMBL SCHEMBL19518055
ZINC ZINC000034016204