| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | R9Y8EY0G42 |
Structure
| InChI Key | AZEXWHKOMMASPA-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C25H20N4O |
| Molecular Weight | 392.46 |
| AlogP | 5.28 |
| Hydrogen Bond Acceptor | 5.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 5.0 |
| Polar Surface Area | 52.83 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 5.0 |
| Heavy Atoms | 30.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Phosphodiesterase
Phosphodiesterase 10
Phosphodiesterase 10A
|
- | 0-3 | - | 0 | - | |
|
Other cytosolic protein
|
- | - | 150-290 | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Schizophrenia | 2 | D012559 | ClinicalTrials |
| Huntington Disease | 2 | D006816 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL562318 |
| DrugBank | DB08387 |
| FDA SRS | R9Y8EY0G42 |
| Guide to Pharmacology | 9617 |
| PDB | PF9 |
| PubChem | 11581936 |
| SureChEMBL | SCHEMBL1414700 |
| ZINC | ZINC000035859742 |
CONTENTS