PROMAZINE

Search structure
Synonyms:
Status: Approved (1956)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: N05AA03
UNII: O9M39HTM5W

Structure
InChI Key ZGUGWUXLJSTTMA-UHFFFAOYSA-N
Smile CN(C)CCCN1c2ccccc2Sc2ccccc21
InChI
InChI=1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H20N2S
Molecular Weight 284.43
AlogP 4.24
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 4.0
Polar Surface Area 6.48
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 20.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2D Cytochrome P450 2D6
- 300 - - -
Enzyme Hydrolase
- 3790 - -
Enzyme Oxidoreductase
- 108000 - 59100 -
Epigenetic regulator Eraser Lysine demethylase Lysine-specific demethylase
- 4707 - - 78.45
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- 5400 - - 65.3
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor
- 1089 - 117 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
- 13 - 126 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- 1040 - 1232 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor
- 3.435-2454.71 - 0.399 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- 23 - 127 -
Membrane receptor
- 3.435-2454.71 - 0.399 -
Surface antigen
5000 - - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- 13 - 13 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters
- 17200 - - 79.2
Transporter
- 11300 - 13 79.2

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 8459
ChEMBL CHEMBL564
DrugBank DB00420
DrugCentral 2284
EPA CompTox DTXSID2023517
FDA SRS O9M39HTM5W
Human Metabolome Database HMDB14564
Guide to Pharmacology 7281
KEGG C07379
PDB P2Z
PharmGKB PA451126
PubChem 4926
SureChEMBL SCHEMBL140489
ZINC ZINC000000010402
CONTENTS