INDOPROFEN

Search structure
Synonyms:
Status: Approved (1979)
Entry Type: Small molecule
Molecule Category: Parent
ATC: M01AE10
UNII: CPE46ZU14N

Structure
InChI Key RJMIEHBSYVWVIN-UHFFFAOYSA-N
Smile CC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1
InChI
InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H15NO3
Molecular Weight 281.31
AlogP 3.04
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 3.0
Polar Surface Area 57.61
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 21.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Cyclooxygenase inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Auxiliary transport protein Fatty acid binding protein family
- - - 1270-161000 -
Enzyme Hydrolase
- - - - 6.947
Enzyme Transferase
- - - - 12.29-27.36
Enzyme
- 20000-21000 - - 12.29-27.36
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- 512.7 - - 82.14-99.73
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Chemokine receptor CXC chemokine receptor
- - - - 56
Other cytosolic protein
1518 - - - -
Transcription factor
1518 - - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 96.18

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 76162
ChEMBL CHEMBL15870
DrugBank DB08951
DrugCentral 1442
EPA CompTox DTXSID5045831
FDA SRS CPE46ZU14N
PubChem 3718
SureChEMBL SCHEMBL25137
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