YM-543

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: KA83KI0EO9

Structure
InChI Key AGJJCLBOHJQGFA-ZQGJOIPISA-N
Smile OC[C@H]1O[C@@H](c2cc(Cc3cc4cccccc-4c3)ccc2O)[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChI=1S/C23H24O6/c24-12-19-20(26)21(27)22(28)23(29-19)17-11-13(6-7-18(17)25)8-14-9-15-4-2-1-3-5-16(15)10-14/h1-7,9-11,19-28H,8,12H2/t19-,20-,21+,22-,23+/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C28H37NO7
Molecular Weight 499.6
AlogP 1.6
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 5.0
Number of Rotational Bond 4.0
Polar Surface Area 110.38
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 29.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Sodium/glucose cotransporter 2 inhibitor PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC05 family of sodium-dependent glucose transporters
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Indications

Mesh Heading Maximum Phase Mesh ID Reference
Diabetes Mellitus, Type 2 2 D003924 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL4297452
FDA SRS KA83KI0EO9
PubChem 11998655
SureChEMBL SCHEMBL4231628
ChEMBL CHEMBL2397450
FDA SRS 00X1DX441H
PubChem 11998655
SureChEMBL SCHEMBL980608
ZINC ZINC000003939471
CONTENTS