| Synonyms: | |
| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | VNM956Y27V |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C18H19FN8O |
| Molecular Weight | 382.4 |
| AlogP | 3.03 |
| Hydrogen Bond Acceptor | 8.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 6.0 |
| Polar Surface Area | 106.43 |
| Molecular species | None |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 28.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Trk family
|
- | 3 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Glioblastoma | 1 | D005909 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3545179 |
| FDA SRS | VNM956Y27V |
| PubChem | 25115967 |
CONTENTS