GSK-1292263

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: R1J57STA6O

Structure
InChI Key AYJRTVVIBJSSKN-UHFFFAOYSA-N
Smile CC(C)c1noc(N2CCC(COc3ccc(-c4ccc(S(C)(=O)=O)cc4)nc3)CC2)n1
InChI
InChI=1S/C23H28N4O4S/c1-16(2)22-25-23(31-26-22)27-12-10-17(11-13-27)15-30-19-6-9-21(24-14-19)18-4-7-20(8-5-18)32(3,28)29/h4-9,14,16-17H,10-13,15H2,1-3H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H28N4O4S
Molecular Weight 456.57
AlogP 3.95
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 7.0
Polar Surface Area 98.42
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 32.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Glucose-dependent insulinotropic receptor agonist
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- - - - 10.92
Enzyme Transferase
- - - - 1.438-29.84
Enzyme
- - - - 1.438-29.84
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -9.76-9.56
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR)
3.4-367.95 - - - -
Membrane receptor Family A G protein-coupled receptor
3.4-367.95 2510.98 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Lipid Metabolism Disorders 2 D052439 ClinicalTrials
Diabetes Mellitus, Type 2 2 D003924 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL3187503
DrugBank DB12627
FDA SRS R1J57STA6O
PubChem 24996872
SureChEMBL SCHEMBL387238
ZINC ZINC000068208690
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