GSK-1292263

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: R1J57STA6O

Structure
InChI Key AYJRTVVIBJSSKN-UHFFFAOYSA-N
Smile CC(C)c1noc(N2CCC(COc3ccc(-c4ccc(S(C)(=O)=O)cc4)nc3)CC2)n1
InChI
InChI=1S/C23H28N4O4S/c1-16(2)22-25-23(31-26-22)27-12-10-17(11-13-27)15-30-19-6-9-21(24-14-19)18-4-7-20(8-5-18)32(3,28)29/h4-9,14,16-17H,10-13,15H2,1-3H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H28N4O4S
Molecular Weight 456.57
AlogP 3.95
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 7.0
Polar Surface Area 98.42
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 32.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Glucose-dependent insulinotropic receptor agonist PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR)
3 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Diabetes Mellitus, Type 2 2 D003924 ClinicalTrials
Lipid Metabolism Disorders 2 D052439 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL3187503
DrugBank DB12627
FDA SRS R1J57STA6O
PubChem 24996872
SureChEMBL SCHEMBL387238
ZINC ZINC000068208690
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