LY-2874455

Search structure
Synonyms:
Status: Phase 1
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: E9M363811V

Structure
InChI Key GKJCVYLDJWTWQU-DUXPYHPUSA-N
Smile CC(Oc1ccc2[nH]nc(/C=C/c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl
InChI
InChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H19Cl2N5O2
Molecular Weight 444.32
AlogP 4.76
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 7.0
Polar Surface Area 88.85
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 30.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Fibroblast growth factor receptor inhibitor PubMed Other

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL3545264
FDA SRS E9M363811V
PubChem 46944259
SureChEMBL SCHEMBL297689
CONTENTS