| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 0361Z8214O |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C23H27ClN4O3 |
| Molecular Weight | 442.95 |
| AlogP | 4.76 |
| Hydrogen Bond Acceptor | 7.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 68.74 |
| Molecular species | None |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 31.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Tyrosine-protein kinase ABL inhibitor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Abl family
|
- | - | - | - | 8 | |
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Csk family
|
- | - | - | - | 0 | |
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Src family
|
- | 5-530 | - | - | 0 | |
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Tec family
|
- | - | - | - | 0 | |
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase VEGFR family
|
- | 670 | - | - | - | |
|
Enzyme
Transferase
|
- | - | - | - | 20.13 | |
|
Epigenetic regulator
Eraser
Histone deacetylase
HDAC class IIb
|
- | - | - | - | 1.62-6.69 |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3545150 |
| FDA SRS | 0361Z8214O |
CONTENTS