EVATANEPAG

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: L266R6E31E

Structure
InChI Key WOHRHWDYFNWPNG-UHFFFAOYSA-N
Smile CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(=O)(=O)c2cccnc2)cc1
InChI
InChI=1S/C25H28N2O5S/c1-25(2,3)21-11-9-19(10-12-21)16-27(33(30,31)23-8-5-13-26-15-23)17-20-6-4-7-22(14-20)32-18-24(28)29/h4-15H,16-18H2,1-3H3,(H,28,29)

Physicochemical Descriptors

Property Name Value
Molecular Formula C25H28N2O5S
Molecular Weight 468.58
AlogP 4.23
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 9.0
Polar Surface Area 96.8
Molecular species ACID
Aromatic Rings 3.0
Heavy Atoms 33.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Prostanoid EP2 receptor agonist PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Prostanoid receptor
0 50 - 50 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Tibial Fractures 2 D013978 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL563646
DrugBank DB12022
FDA SRS L266R6E31E
Guide to Pharmacology 1929
PDB GM9
PubChem 9890801
SureChEMBL SCHEMBL533264
ZINC ZINC000001494905
CONTENTS