GSK-2239633

Search structure


Synonyms:	Gsk-2239633 GSK2239633 Gsk-2239633a GSK 2239633A
Status:	Phase 1
Entry Type:	Small molecule
Molecule Category:	UNKNOWN
UNII:	07ODS257BP

Structure


InChI Key	JVBQEIRQUCWMTR-UHFFFAOYSA-N
Smile	COc1cccc2c1c(NS(=O)(=O)c1ccc(Cl)s1)nn2Cc1cccc(NC(=O)CO)c1
InChI	InChI=1S/C21H19ClN4O5S2/c1-31-16-7-3-6-15-20(16)21(25-33(29,30)19-9-8-17(22)32-19)24-26(15)11-13-4-2-5-14(10-13)23-18(28)12-27/h2-10,27H,11-12H2,1H3,(H,23,28)(H,24,25)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H19ClN4O5S2
Molecular Weight	506.99
AlogP	3.54
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	8.0
Polar Surface Area	122.55
Molecular species	ACID
Aromatic Rings	4.0
Heavy Atoms	33.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Chemokine receptor CC chemokine receptor	-	-	-	10	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Asthma	1	D001249	ClinicalTrials

Related Entries

Scaffolds

Target Level :

Level 3

Level 4

Level 5

Level 6

Extend network:

Indication

Mechanism of Action

Primary Target

Target Level

Cross References

Resources	Reference
ChEMBL	CHEMBL2178575
FDA SRS	07ODS257BP
PubChem	46861584

CONTENTS