AMG-208

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: Y2SR66P7VM

Structure
InChI Key HEAIZQNMNCHNFD-UHFFFAOYSA-N
Smile COc1ccc2c(OCc3nnc4ccc(-c5ccccc5)nn34)ccnc2c1
InChI
InChI=1S/C22H17N5O2/c1-28-16-7-8-17-19(13-16)23-12-11-20(17)29-14-22-25-24-21-10-9-18(26-27(21)22)15-5-3-2-4-6-15/h2-13H,14H2,1H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H17N5O2
Molecular Weight 383.41
AlogP 3.93
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 5.0
Polar Surface Area 74.43
Molecular species NEUTRAL
Aromatic Rings 5.0
Heavy Atoms 29.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Hepatocyte growth factor receptor inhibitor PubMed Other
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 3 Cytochrome P450 family 3A Cytochrome P450 3A4
- 4100-32000 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Met family
- 9-46 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Neoplasms 1 D009369 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 90626
ChEMBL CHEMBL496102
DrugBank DB08079
EPA CompTox DTXSID70143039
FDA SRS Y2SR66P7VM
PDB L5G
PubChem 24864821
SureChEMBL SCHEMBL9910136
ZINC ZINC000034285235
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