OSI-632

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: W1B375O5M2

Structure
InChI Key HXHAJRMTJXHJJZ-UHFFFAOYSA-N
Smile NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1
InChI
InChI=1S/C20H24BrF2N5O3S/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30)

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H24BrF2N5O3S
Molecular Weight 532.41
AlogP 3.86
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 10.0
Polar Surface Area 109.58
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 32.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Vascular endothelial growth factor receptor 2 inhibitor PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase DDR family
- 24-450 422 - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Tie family
- 18-620 - - -
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family
- 6-11 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Peritoneal Neoplasms 2 D010534 ClinicalTrials
Fallopian Tube Neoplasms 2 D005185 ClinicalTrials
Ovarian Neoplasms 2 D010051 ClinicalTrials
Macular Degeneration 1 D008268 ClinicalTrials
Diabetic Retinopathy 1 D003930 ClinicalTrials
Lung Neoplasms 1 D008175 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL253969
DrugBank DB12962
EPA CompTox DTXSID00179866
FDA SRS W1B375O5M2
Guide to Pharmacology 7881
PDB BFF
SureChEMBL SCHEMBL187261
ZINC ZINC000003834191
CONTENTS