RIPASUDIL

Search structure
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 11978226XX

Structure
InChI Key QSKQVZWVLOIIEV-NSHDSACASA-N
Smile C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(F)c12
InChI
InChI=1S/C15H18FN3O2S/c1-11-8-17-6-3-7-19(11)22(20,21)14-5-2-4-12-9-18-10-13(16)15(12)14/h2,4-5,9-11,17H,3,6-8H2,1H3/t11-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H18FN3O2S
Molecular Weight 323.39
AlogP 1.75
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 62.3
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Rho-associated protein kinase inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase DMPK family AGC protein kinase ROCK subfamily
- 3.8-197 33 330 -
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase PKC family AGC protein kinase PKC delta subfamily
- - 2470 - -
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase PKN family
- - 285 - -
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase CAMK1 family CAMK protein kinase AMPK subfamily
- - 3269 - -
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase CAMK1 family CAMK protein kinase MARK subfamily
- - 58240 - -
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase PKD family
- - 3703 - -
Enzyme Kinase Protein Kinase CMGC protein kinase group CMGC protein kinase CDK family CMGC protein kinase CDK9 subfamily
- - 13279 - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase AUR family
- - 1152 - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase PLK family
- - 8141 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase KHS subfamily
- - 3219 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE20 family STE protein kinase TAO subfamily
- - 11799 - -
Enzyme Kinase Protein Kinase STE protein kinase group STE protein kinase STE7 family
- - 3079 - -
Enzyme Kinase Protein kinase regulatory subunit
- - 1807 - -
Enzyme Oxidoreductase
- - 3699 - -
Enzyme Transferase
- - - - -5.547-7.07
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- - - - -12.89-1.52

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Fuchs' Endothelial Dystrophy 3 D005642 ClinicalTrials
Corneal Edema 3 D015715 ClinicalTrials
Fuchs' Endothelial Dystrophy 3 D005642 ClinicalTrials
Retinopathy of Prematurity 1 D012178 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 136046
ChEMBL CHEMBL3426621
DrugBank DB13165
DrugCentral 4938
FDA SRS 11978226XX
Guide to Pharmacology 10423
PubChem 9863672
SureChEMBL SCHEMBL31542
ZINC ZINC000003940873
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