AZD-1236

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: B4OQY51WZS

Structure
InChI Key SFJFBTPHDHUUPU-OAHLLOKOSA-N
Smile C[C@]1(CS(=O)(=O)N2CCC(Oc3ccc(Cl)cn3)CC2)NC(=O)NC1=O
InChI
InChI=1S/C15H19ClN4O5S/c1-15(13(21)18-14(22)19-15)9-26(23,24)20-6-4-11(5-7-20)25-12-3-2-10(16)8-17-12/h2-3,8,11H,4-7,9H2,1H3,(H2,18,19,21,22)/t15-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H19ClN4O5S
Molecular Weight 402.86
AlogP 0.51
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 5.0
Polar Surface Area 117.7
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 26.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Matrix metalloproteinase 12 inhibitor Other PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Pulmonary Disease, Chronic Obstructive 2 D029424 ClinicalTrials
Cystic Fibrosis 2 D003550 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4297352
DrugBank DB11961
EPA CompTox DTXSID30647184
FDA SRS B4OQY51WZS
Guide to Pharmacology 7844
PubChem 24751752
SureChEMBL SCHEMBL942315
ZINC ZINC000059688588
CONTENTS