| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | XH93U6NIJE |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C25H23FN8O2S2 |
| Molecular Weight | 550.65 |
| AlogP | 4.15 |
| Hydrogen Bond Acceptor | 10.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 109.57 |
| Molecular species | None |
| Aromatic Rings | 5.0 |
| Heavy Atoms | 38.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Hepatocyte growth factor receptor inhibitor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Met family
|
- | 4-204 | 0.9 | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Neoplasms | 2 | D009369 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3545325 |
| FDA SRS | XH93U6NIJE |
| PubChem | 25182860 |
CONTENTS