| Synonyms: | |
| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 33639WNC7Q |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C19H22N4O3 |
| Molecular Weight | 354.41 |
| AlogP | 1.13 |
| Hydrogen Bond Acceptor | 5.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 3.0 |
| Polar Surface Area | 78.53 |
| Molecular species | None |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 26.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | PI3-kinase p110-beta subunit inhibitor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Cytochrome P450
Cytochrome P450 family 3
Cytochrome P450 family 3A
Cytochrome P450 3A4
|
- | 40000 | - | - | - | |
|
Enzyme
Kinase
Protein Kinase
AGC protein kinase group
AGC protein kinase AKT family
|
- | 16-27 | - | - | - | |
|
Enzyme
Kinase
Protein Kinase
Atypical protein kinase group
Atypical protein kinase PIKK family
|
- | 2000 | - | - | - | |
|
Enzyme
Transferase
|
- | 23-60 | - | - | 23.41 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Neoplasms | 1 | D009369 | ClinicalTrials |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3545008 |
| FDA SRS | 33639WNC7Q |
| PubChem | 135565159 |
CONTENTS