DUVOGLUSTAT HYDROCHLORIDE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 0RN23C42QR

Structure
InChI Key ZJIHMALTJRDNQI-VFQQELCFSA-N
Smile Cl.OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChI=1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5-,6-;/m1./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C6H14ClNO4
Molecular Weight 199.63
AlogP -2.97
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 5.0
Number of Rotational Bond 1.0
Polar Surface Area 92.95
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 11.0

Pharmacology

Action Mechanism of Action Reference
STABILISER Lysosomal alpha-glucosidase stabiliser PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor
- 10000 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Glycogen Storage Disease Type II 2 D006009 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL460785
FDA SRS 0RN23C42QR
PubChem 13018787
SureChEMBL SCHEMBL1320203
CONTENTS