MIVAVOTINIB CITRATE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 6ZJ8V3Q0H1

Structure
InChI Key ZVPYVZMKBQYKQG-ZVWHLABXSA-N
Smile Cn1cc(-c2nc(N[C@@H]3CCCC[C@@H]3N)c(F)c3c2C(=O)NC3)cn1.O=C(O)CC(O)(CC(=O)O)C(=O)O
InChI
InChI=1S/C17H21FN6O.C6H8O7/c1-24-8-9(6-21-24)15-13-10(7-20-17(13)25)14(18)16(23-15)22-12-5-3-2-4-11(12)19;7-3(8)1-6(13,5(11)12)2-4(9)10/h6,8,11-12H,2-5,7,19H2,1H3,(H,20,25)(H,22,23);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t11-,12+;/m0./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H29FN6O8
Molecular Weight 536.52
AlogP 1.55
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 3.0
Polar Surface Area 97.86
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 25.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Tyrosine-protein kinase SYK inhibitor Other Other

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Lymphoma, Large B-Cell, Diffuse 2 D016403 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials
Lymphoma 1 D008223 ClinicalTrials
Lymphoma, Non-Hodgkin 1 D008228 ClinicalTrials
Ovarian Neoplasms 1 D010051 ClinicalTrials
Lymphoma, Follicular 1 D008224 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4594253
FDA SRS 6ZJ8V3Q0H1
PubChem 118980937
SureChEMBL SCHEMBL17632419
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