APILIMOD

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: GFW2K84S4L

Structure
InChI Key HSKAZIJJKRAJAV-KOEQRZSOSA-N
Smile Cc1cccc(/C=N/Nc2cc(N3CCOCC3)nc(OCCc3ccccn3)n2)c1
InChI
InChI=1S/C23H26N6O2/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28)/b25-17+

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H26N6O2
Molecular Weight 418.5
AlogP 3.08
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 8.0
Polar Surface Area 84.76
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 31.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR 1-phosphatidylinositol 3-phosphate 5-kinase inhibitor PubMed PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Crohn Disease 2 D003424 ClinicalTrials
Severe Acute Respiratory Syndrome 2 D045169 ClinicalTrials
Common Variable Immunodeficiency 1 D017074 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4297643
DrugBank DB05611
FDA SRS GFW2K84S4L
Guide to Pharmacology 9859
PubChem 10173277
SureChEMBL SCHEMBL426299
ZINC ZINC000011726230
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