RIPASUDIL HYDROCHLORIDE DIHYDRATE

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 016TTR32QF

Structure
InChI Key CMDJNMACGABCKQ-XVSRHIFFSA-N
Smile C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(F)c12.Cl.O.O
InChI
InChI=1S/C15H18FN3O2S.ClH.2H2O/c1-11-8-17-6-3-7-19(11)22(20,21)14-5-2-4-12-9-18-10-13(16)15(12)14;;;/h2,4-5,9-11,17H,3,6-8H2,1H3;1H;2*1H2/t11-;;;/m0.../s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H23ClFN3O4S
Molecular Weight 395.88
AlogP 1.75
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 62.3
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Rho-associated protein kinase inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase DMPK family AGC protein kinase ROCK subfamily
- 21.36 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Fuchs' Endothelial Dystrophy 2 D005642 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL4594454
FDA SRS 016TTR32QF
SureChEMBL SCHEMBL20557243
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