OLMESARTAN MEDOXOMIL

Search structure
Synonyms:
Status: Approved (2002)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: C09CA08
UNII: 6M97XTV3HD

Structure
InChI Key UQGKUQLKSCSZGY-UHFFFAOYSA-N
Smile CCCc1nc(C(C)(C)O)c(C(=O)OCc2oc(=O)oc2C)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
InChI
InChI=1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)

Physicochemical Descriptors

Property Name Value
Molecular Formula C29H30N6O6
Molecular Weight 558.6
AlogP 4.17
Hydrogen Bond Acceptor 11.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 10.0
Polar Surface Area 162.16
Molecular species ACID
Aromatic Rings 5.0
Heavy Atoms 41.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Type-1 angiotensin II receptor antagonist DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- 977 - 540 10-37
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
- 4730 - - -
Transporter Primary active transporter ATP-binding cassette ABCC subfamily
- 2000 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Proteinuria 3 D011507 ClinicalTrials
Kidney Diseases 3 D007674 ClinicalTrials
Diabetic Nephropathies 3 D003928 ClinicalTrials
Atherosclerosis 3 D050197 ClinicalTrials
Essential Hypertension 3 D000075222 ClinicalTrials
Glomerulonephritis 2 D005921 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 31932
ChEMBL CHEMBL1200692
DrugCentral 1985
EPA CompTox DTXSID9045924
FDA SRS 6M97XTV3HD
Guide to Pharmacology 591
PharmGKB PA164742950
SureChEMBL SCHEMBL16403
ZINC ZINC000004149248
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