Synonyms: | |
Status: | Approved (2023) |
Entry Type: | Small molecule |
Molecule Category: | Parent |
UNII: | 6O01GMS00P |
InChI Key | ZVHNDZWQTBEVRY-UHFFFAOYSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C23H22N6O2 |
Molecular Weight | 414.47 |
AlogP | 2.98 |
Hydrogen Bond Acceptor | 7.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 6.0 |
Polar Surface Area | 103.17 |
Molecular species | NEUTRAL |
Aromatic Rings | 3.0 |
Heavy Atoms | 31.0 |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase JakA family
|
- | 11-41 | - | - | 95 | |
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase JakB family
|
- | 11-41 | - | - | 95 |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Primary Myelofibrosis | 3 | D055728 | ClinicalTrials |
Carcinoma, Pancreatic Ductal | 3 | D021441 | ClinicalTrials |
Primary Myelofibrosis | 3 | D055728 | ClinicalTrials |
Thrombocythemia, Essential | 2 | D013920 | ClinicalTrials |
Polycythemia Vera | 2 | D011087 | ClinicalTrials |
Carcinoma, Non-Small-Cell Lung | 1 | D002289 | ClinicalTrials |
Resources | Reference |
---|---|
ChEBI | 91407 |
ChEMBL | CHEMBL1078178 |
DrugBank | DB11763 |
FDA SRS | 6O01GMS00P |
Guide to Pharmacology | 7791 |
PDB | C87 |
SureChEMBL | SCHEMBL2237234 |
ZINC | ZINC000043199890 |