Synonyms:
Status: Approved (2009)
Entry Type: Protein
Molecule Category: UKNOWN
ATC: L01XG02
UNII: 72X6E3J5AR

Structure

InChI Key BLMPQMFVWMYDKT-NZTKNTHTSA-N
Smile CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1
InChI
InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C40H57N5O7
Molecular Weight 719.92
AlogP 2.58
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 20.0
Polar Surface Area 158.47
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 52.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR 26S proteosome inhibitor FDA PubMed

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Multiple Myeloma 4 D009101 ClinicalTrials
Neoplasms 4 D009369 ClinicalTrials
Waldenstrom Macroglobulinemia 3 D008258 ClinicalTrials
Kidney Neoplasms 2 D007680 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 2 D064129 ClinicalTrials
Graft vs Host Disease 2 D006086 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Carcinoma, Neuroendocrine 2 D018278 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
Lymphoma, Mantle-Cell 2 D020522 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Leukemia, Plasma Cell 1 D007952 ClinicalTrials
Plasmacytoma 1 D010954 ClinicalTrials
Leukemia, Prolymphocytic 1 D015463 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 D054198 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials
Leukemia 1 D007938 ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-Cell 1 D015451 ClinicalTrials
Lymphoma, T-Cell, Peripheral 1 D016411 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 1 D016403 ClinicalTrials
Small Cell Lung Carcinoma 1 D055752 ClinicalTrials
Lymphoma, Non-Hodgkin 1 D008228 ClinicalTrials
Sezary Syndrome 1 D012751 ClinicalTrials
Mycosis Fungoides 1 D009182 ClinicalTrials
Amyloidosis 1 D000686 ClinicalTrials
Amyloidosis 1 D000686 ClinicalTrials
Hodgkin Disease 1 D006689 ClinicalTrials

Cross References

Resources Reference
ChEBI 65347
ChEMBL CHEMBL451887
DrugBank DB08889
DrugCentral 4483
EPA CompTox DTXSID4048690
FDA SRS 72X6E3J5AR
Guide to Pharmacology 7420
PharmGKB PA166165203
SureChEMBL SCHEMBL85165
ZINC ZINC000049841054