Synonyms: | |
Status: | Approved (1993) |
Entry Type: | Small molecule |
Molecule Category: | Parent |
ATC: | R06AX13 |
UNII: | 7AJO3BO7QN |
InChI Key | JCCNYMKQOSZNPW-UHFFFAOYSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C22H23ClN2O2 |
Molecular Weight | 382.89 |
AlogP | 4.89 |
Hydrogen Bond Acceptor | 3.0 |
Hydrogen Bond Donor | 0.0 |
Number of Rotational Bond | 1.0 |
Polar Surface Area | 42.43 |
Molecular species | NEUTRAL |
Aromatic Rings | 2.0 |
Heavy Atoms | 27.0 |
Action | Mechanism of Action | Reference |
---|---|---|
ANTAGONIST | Histamine H1 receptor antagonist | PubMed |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Hypersensitivity | 4 | D006967 | ClinicalTrials |
Rhinitis, Allergic, Seasonal | 4 | D006255 | ClinicalTrials |
Urticaria | 4 | D014581 | ClinicalTrials |
Asthma | 3 | D001249 | ClinicalTrials |
Back Pain | 2 | D001416 | ClinicalTrials |
Eosinophilic Esophagitis | 2 | D057765 | ClinicalTrials |
Breast Neoplasms | 2 | D001943 | ClinicalTrials |
Arthritis, Rheumatoid | 1 | D001172 | ClinicalTrials |
Multiple Sclerosis | 1 | D009103 | ClinicalTrials |
Dermatitis, Atopic | 1 | D003876 | ClinicalTrials |
Multiple Myeloma | 0 | D009101 | ClinicalTrials |
Lymphoma | 0 | D008223 | ClinicalTrials |
Resources | Reference |
---|---|
ChEBI | 6538 |
ChEMBL | CHEMBL998 |
DrugBank | DB00455 |
DrugCentral | 1605 |
EPA CompTox | DTXSID2023224 |
FDA SRS | 7AJO3BO7QN |
Human Metabolome Database | HMDB0005000 |
Guide to Pharmacology | 7216 |
PharmGKB | PA450266 |
SureChEMBL | SCHEMBL4596 |
ZINC | ZINC000000537931 |