LINSITINIB

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 15A52GPT8T

Structure
InChI Key PKCDDUHJAFVJJB-VLZXCDOPSA-N
Smile C[C@]1(O)C[C@@H](c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c3c(N)nccn32)C1
InChI
InChI=1S/C26H23N5O/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16/h2-13,19,32H,14-15H2,1H3,(H2,27,28)/t19-,26+

Physicochemical Descriptors

Property Name Value
Molecular Formula C26H23N5O
Molecular Weight 421.5
AlogP 4.82
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 89.33
Molecular species NEUTRAL
Aromatic Rings 5.0
Heavy Atoms 32.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Insulin-like growth factor I receptor inhibitor PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase InsR family
- 2-24 - - -
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
2090 - - - -
Transporter Primary active transporter ATP-binding cassette ABCG subfamily
104 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Adrenal Cortex Neoplasms 3 D000306 ClinicalTrials
Small Cell Lung Carcinoma 2 D055752 ClinicalTrials
Carcinoma, Hepatocellular 2 D006528 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Sarcoma, Ewing 2 D012512 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Head and Neck Neoplasms 2 D006258 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials
Breast Neoplasms 2 D001943 ClinicalTrials
Colorectal Neoplasms 1 D015179 ClinicalTrials
Skin Neoplasms 1 D012878 ClinicalTrials
Ovarian Neoplasms 1 D010051 ClinicalTrials
Carcinoma, Squamous Cell 1 D002294 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL1091644
DrugBank DB06075
FDA SRS 15A52GPT8T
Guide to Pharmacology 7423
SureChEMBL SCHEMBL400735
ZINC ZINC000100071817
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