Synonyms: | |
Status: | Approved (1991) |
Entry Type: | Small molecule |
Molecule Category: | Parent |
ATC: | C09AA05 |
UNII: | L35JN3I7SJ |
InChI Key | HDACQVRGBOVJII-JBDAPHQKSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C23H32N2O5 |
Molecular Weight | 416.52 |
AlogP | 2.38 |
Hydrogen Bond Acceptor | 5.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 9.0 |
Polar Surface Area | 95.94 |
Molecular species | ACID |
Aromatic Rings | 1.0 |
Heavy Atoms | 30.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | Angiotensin-converting enzyme inhibitor | FDA |
Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
---|---|---|---|---|---|---|
Enzyme
Protease
Metallo protease
Metallo protease MAE clan
Metallo protease M2 family
|
- | 253-253 | - | - | - |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Coronary Disease | 4 | D003327 | ClinicalTrials |
Diabetes Mellitus | 4 | D003920 | ClinicalTrials |
Myocardial Infarction | 4 | D009203 | ClinicalTrials |
Glucose Intolerance | 3 | D018149 | ClinicalTrials |
Atherosclerosis | 3 | D050197 | ClinicalTrials |
Glomerulonephritis | 3 | D005921 | ClinicalTrials |
Atrial Flutter | 3 | D001282 | ClinicalTrials |
Renal Insufficiency, Chronic | 3 | D051436 | ClinicalTrials |
Diabetes Mellitus, Type 1 | 3 | D003922 | ClinicalTrials |
Heart Diseases | 3 | D006331 | ClinicalTrials |
Diabetic Nephropathies | 3 | D003928 | ClinicalTrials |
Atrial Fibrillation | 3 | D001281 | ClinicalTrials |
Myocardial Ischemia | 3 | D017202 | ClinicalTrials |
Hypercholesterolemia | 3 | D006937 | ClinicalTrials |
Metabolic Diseases | 3 | D008659 | ClinicalTrials |
Diabetes Mellitus, Type 2 | 3 | D003924 | ClinicalTrials |
Albuminuria | 3 | D000419 | ClinicalTrials |
Severe Acute Respiratory Syndrome | 2 | D045169 | ClinicalTrials |
Lupus Erythematosus, Systemic | 2 | D008180 | ClinicalTrials |
Arthritis, Rheumatoid | 2 | D001172 | ClinicalTrials |
Kidney Diseases | 2 | D007674 | ClinicalTrials |
Metabolic Syndrome | 0 | D024821 | ClinicalTrials |
Resources | Reference |
---|---|
ChEBI | 8774 |
ChEMBL | CHEMBL1168 |
DrugBank | DB00178 |
DrugCentral | 2356 |
EPA CompTox | DTXSID8023551 |
FDA SRS | L35JN3I7SJ |
Human Metabolome Database | HMDB0014324 |
Guide to Pharmacology | 6339 |
PharmGKB | PA451223 |
SureChEMBL | SCHEMBL16059 |
ZINC | ZINC000003798757 |